2nd INTEGRATIVE STRUCTURAL BIOLOGY MEETING
November 29th to December 3rd 2021
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Program and Schedule
program overview
Detailed Scientific program
Monday 29th November
13:00 Welcome
13:45 DNA/RNA Worlds I
Valérie LAMOUR, IGBMC, Illkirch (30 min)
Structural basis for allosteric regulation of Human Topoisomerase IIα
Romain KOSZUL, Institut Pasteur, Paris (30 min)
Arrays of transcriptional units represent the structural functional matrix of the bacterial chromosome
Marcin J. SUSKIEWICZ, CBM, Orléans (20 min)
Structural and mechanistic insights into PARP1 and PARP2 function and PARP inhibitor response
Xavier MANIVAL, IMOPA, Nancy (20 min)
The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity
Claire CARGEMEL, I2BC, Gif-sur-Yvette (20 min)
DciA, the ancestral replicative helicase loader
15:45 Keynote
Andrea CARFI, Moderna (by WebConference)
Development of the Moderna mRNA vaccine against COVID-19
16:15 Coffee break
16:45 DNA/RNA Worlds II
Emmanuelle SCHMITT, Ecole polytechnique, Palaiseau (30 min)
Translation initiation in Archaea
Julien MARQUEVIELLE, IECB/ARNA, Bordeaux (20 min)
NMR study of a RNA G-quadruplex forming sequence within HIV-1 U3 region
Can WANG, BIOC, Ecole polytechnique, Palaiseau (20 min)
Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator
Carine TISNE, IBPC, Paris (20 min)
Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs
Thomas GREGOR, Institut Pasteur, Paris (20 min, by WebConference)
Linking DNA polymer and transcription dynamics
19h00 Evening : Welcome cocktail
Tuesday 30th November
8:30 Macromolecular Assemblies
Xiaojing CONG, IGF, Montpellier (30 min)
Molecular insights into the biased signaling mechanism of the mu-opioid receptor
Stéphane ROCHE, I2BC, Gif-sur-Yvette (20 min)
High Resolution CryoEM Structure and Assembly Mechanism of a Bacterial Virus Genome Gatekeeper
Lu YANG, Institut Pasteur, Paris (20 min)
The actinobacterial exception: 2.3 Å resolution cryo-EM structure of a large enzymatic machinery from a central metabolic supercomplex
Sayma ZAHID, I2BC, Gif-sur-Yvette (20 min)
Structural and functional study of the complex formed by the Werner protein (WRN) and the Ku70/Ku80 heterodimer
Helgo SCHMIDT, IGBMC, Illkirch (20 min)
The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1
10:30 Coffee break
11:00 Health issues I
Juan REGUERA, AFMB, Marseille (30 min)
Alphavirus nsP1 capping rings are functional gates of membranous viral factories
Rémi FRONZES, IECB, Bordeaux (30 min)
The mycoplasma surface proteins MIB and MIP: an antibody degrading device.
Rania GHOUIL, I2BC, Gif-sur-Yvette (20 min)
A cryptic motif in BRCA2 triggers oligomerization of the meiotic HSF2BP, as characterized by NMR, X-ray crystallography and cryo-electron microscopy
Xavier HANOULLE, Integrative Structural Biology Lab, Lille (20 min)
NMR of SARS-CoV-2 Main Protease (3CLpro) for drug development
Célia CAILLET-SAGUY, Institut Pasteur, Paris (20 min)
Host PDZ-containing proteins targeted by Hepatitis B virus and SARS-CoV-2
13:00 Lunch
13:45 Poster session
14:30 Sponsor presentation
Jean-Philippe BOURSIER (Cytiva)
Introduction of a new biocompatible liquid chromatography device dedicated to micro-purification: the ÄKTA Pure micro
Linda TCHATCHOUANG (Genscript)
How does GenScript Support Structural Biology Research
Sacha DE CARLO (SPT Labtech)
Routine CryoEM Sample Optimization with chameleon
15:00 Keynote
Jonas RIES, EMBL, Heidelberg, Germany
Super Resolution microscopy for structural cell biology
15:30 Formation tout au long de la vie
Sandrine DELACROIX-MORVAN, France Université Numérique
Not communicated
Fabrice CORDELIERES, France Bio Imaging
Le passeport formation France BioImaging
Dominique HOUSSET, French Infrastructure for Integrated Biology
Biologie Structurale Intégrative : Un cours dont vous êtes le héros
16:30 Round Table
Animée par Cécile MICHAUT (Journaliste Scientifique)
17:00-18:30 Satellite session "Atelier pour la création d'un forum des plateformes/services de cristallo"
Animé par Mirjam Czjzek et Pascal Retailleau
Wednesday 1st December
8:30 Integral & peripheral membrane proteins
Agata NAWROTEK, ENS Paris-Saclay, Gif-sur-Yvette (30 min)
Regulation of small GTPase signaling at the periphery of membrane
Vincent CHAPTAL, IBCP, Lyon (20 min)
CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, Nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer
Laurent CATOIRE, IBPC, Paris (20 min)
Study of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure
Robert QUAST, CBS, Montpellier (20 min)
Dissecting the allosteric modulation of the Metabotropic Glutamate Receptor 2 using single molecule FRET
Guillaume LEBON, IGF, Montpellier (20 min)
Structural basis of the human mGlu5 receptor activation mechanism
10:30 Coffee break
11h00 IDP and membrane-less compartmentalization
Andrea PARMEGGIANI, L2C, Montpellier (30 min, by WebConference)
Biophysical Principles for DNA Active Segregation in Bacteria
Stefan AROLD, KAUST, Thuwal, Arabie Saoudite (20 min)
Kinase control through a highly disordered dimerization and calmodulin-binding element
Quentin NEVERS, I2BC, Gif-sur-Yvette (20 min)
Identification of structural elements required for the formation of rabies virus phosphoprotein and nucleoprotein inclusions in different minimal systems
Christina SIZUN, ICSN, Gif-sur-Yvette (20 min)
A structural and dynamic analysis of a viral platform protein
Marjolaine NOIRCLERC-SAVOYE, IBS, Grenoble (20 min)
HIV-1 Rev bound to human Importin beta : an integrative study of a protein complex
13:00 Lunch
13:45 Poster session
14:30 Sponsor presentation
Amandine GONTIER (Dynamic Biosensor)
heliX® : a next generation modular biosensor for interaction and conformation analysis
Tomas DE GARAY (Refeyn)
Mass photometry – a revolutionary approach to bioanalytics
Daniel MATHIEU (Bruker BioSpin)
Streamlining NMR in Structural Biology
15:00 Keynote
Simon ALBERTI, Max Planck Institute, Dresden, Germany
Biomolecular condensates at the nexus of cellular stress, aging and disease
15:30 Drug design
Maria DUCA, ICN, Nice (30 min)
Targeting non-coding RNAs with synthetic small molecules for innovative therapeutic applications
Axel INNIS, IECB, Bordeaux (30 min)
Context-dependent inhibition of protein synthesis by ribosome-targeting antibiotics
Laurent MAVEYRAUD, IPBS, Toulouse (20 min)
Inhibition of mycobacterial phosphopantetheinyl transferases
Magali MATHIEU, SANOFI, Vitry-sur-Seine (20 min)
KRAS G12C fragment screening renders new binding pockets
Eric ENNIFAR, Unistra, Strasbourg (20 min)
Characterization of the 5’-UTR elements regulating beta-catenin translation in cancer
17:30 Round Table "Academy / Industry interaction"
with Olivier NOSJEAN, Research Scientific Director, Servier, Croissy-sur-Seine
Darren HART, FRISBI, director Grenoble Center and Director of Integrated Structural Biology Grenoble (ISBG), IBS, Grenoble
Hélène CHAUTARD, Directrice du pôle science de la vie, de la Direction de l’Investissement de la SATT Paris-Saclay
Claude NOGUES, Directrice Scientifique de Kimialys, Paris
Nora BENHABILES, Directrice adjointe de la division Recherche fondamental en charge de l’innovation, valorisation et Start-up Spin-off, CEA, Saclay
Thursday 2nd December
8:30 Health issues II
Alain MARTY, LISBP, Toulouse (30 min)
Enzymes: innovative solutions for reinventing the lifecycle of plastics
Oriane FRANCES, Sanofi, Vitry-sur-Seine (30 min)
NMR input in the characterization of therapeutical mAbs
Marc LENSINK, UGSF, Lille (20 min)
The CAPRI covid-19 Open Science Initiative
Faustine HENOT, IBS, Grenoble (20 min)
Human HSP90 a contortionist drug target : Modulation of its energy landscape upon ligand binding
Carlos A. ELENA-REAL, CBS, Montpellier (20 min)
High-resolution characterization of pathogenic and non-pathogenic Huntingtin protein poly-Q tracts
10:30 Coffee break
11:00 Methodologies I
Sabine HEDIGER, IRIG, Grenoble (30 min)
Unraveling binding sites by selective DNP-enhanced NMR
Claude SAUTER, Unistra, Strasbourg (20 min)
Serial crystallography: a game-changer in crystallization and crystal handling
Martin WEIK, IBS, Grenoble (20 min)
Photoenzyme at work: Structural dynamics of fatty acid photodecarboxylase
Marie LEY, Unistra, Strasbourg (20 min)
Integration of mass spectrometry data to structural biology for the characterization of PRMT2/RSF1 interaction
12:30 Keynote
Irina GUTSCHE, IBS, Grenoble
Integrative structural biology analysis of an enterobacterial stress response protein triad
13:00 Lunch
13:45 Poster session
14:30 SFB Prizes
SFB Prize 2019: Emmanuelle BIGNON, LPCT Université de Lorraine Nancy
Understanding the dynamics and reactivity of nucleic acids to fight against pathologies
SFB Prize 2021 : to be announced (by WebConference)
15:30 Round Table "Science et société"
"La parole scientifique dans l’espace public"
Sylvestre HUET, Journaliste scientifique, auteur du blog {Sciences²}
Etienne KLEIN, Physicien et philosophe des sciences, auteur de l'essai "le goût du vrai"
Mathias GIREL, Philosophe des sciences, auteur de "sciences et territoires de l'ignorance"
Hervé DOLE, Vice-président de l'Université Paris-Saclay en charge de "art, culture, science et société", astrophysicien à l'IAS-Orsay
Stéphanie ATGER, Députée de la 6ème circonscription de l'Essonne
Evening : Gala dinner
Friday 3rd December
8:30 Methodologies II
Sigrid MILLES, IBS, Grenoble (30 min)
Analysing the conformational landscape of IDPs by integrated NMR and smFRET
Florent DELHOMMEL, Bavarian NMR Center, Technical University Of Munich / Institute Of Structural Biology, Germany (15 min)
NMR and structural characterization of NudC, a co-chaperone involved in client-transfer between heat shock proteins
Adeline ROBIN, IBS, Grenoble (15 min)
Fragment-based drug discovery on lactate dehydrogenase crystals grown in presence of Crystallophore.
Angela MANTOVANELLI, IBS, Grenoble (15 min)
The Photoswitching Mechanism of the Fluorescent Protein rsEGFP2 at Cryogenic Temperature
Leo CHAVAS, Nagoya University, Synchrotron Radiation Research Center, Japan (15 min)
Combining expert methods for multi-scale and correlated analysis, by WebConference
10:00 Coffee break
10:30 Infrastructures
Eric GUITTET,
Chargé de mission Secteur Biologie Santé, Ministère en charge de l’enseignement supérieur et de la recherche
Daniel BOUJARD,
Directeur Adjoint Scientifique (DAS) du pôle Infrastructures nationales, Plateformes de l’INSB, CNRS
Jean-Pierre SIMORRE,
Délégué scientifique des grandes infrastructures de recherche de l’INC, CNRS
Bruno KLAHOLZ,
Responsable de l’infrastructure FRISBI
Carine VAN HEIJENOORT,
Responsable de l’Infrastructure InfrAnalytics
Béatrice SATIAT-JEUNEMAITRE,
Représentante FBI
Jean SUSINI
Directeur scientifique du synchrotron Soleil
12:50 Conclusion
13:00 Lunch Box
14:00-16:30 Satellite session Alphafold
Randy READ (Cambridge University, UK) by WebConference
Structural biology in a post-AlphaFold world
Raphaël GUEROIS (I2BC, Gif-sur-Yvette)
Feedback on the use of Alphafold for protein interaction prediction and modeling
Irène BARBARIN-BOCAHU (BIOC, Palaiseau)
Artificial intelligence to solve the X-ray crystallography phase problem : a case study report.
Discussions