2nd INTEGRATIVE STRUCTURAL BIOLOGY MEETING
November 29th to December 3rd 2021
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Program and Schedule
program overview
Detailed Scientific program
Monday 29th November
13:00 Welcome
13:45 DNA world
Chair: Dr TIMMINS
Valérie LAMOUR, IGBMC, Illkirch (30 min)
Romain KOSZUL, Institut Pasteur, Paris (30 min)
Marcin J. SUSKIEWICZ, CBM, Orléans (20 min)
Structural and mechanistic insights into PARP1 and PARP2 function and PARP inhibitor response
Xavier MANIVAL, IMOPA, Nancy (20 min)
The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity
Claire CARGEMEL, I2BC, Gif-sur-Yvette (20 min)
DciA, the ancestral replicative helicase loader
15:45 Keynote
Andrea CARFI, Moderna
16:15 Coffee break
15:30 RNA world
Chair: Drs Nollmann and Gervais
Thomas GREGOR, Institut Pasteur, Paris (30 min)
Emmanuelle SCHMITT, Ecole polytechnique, Palaiseau (30 min)
Translation initiation in Archaea
Can WANG, BIOC, Ecole polytechnique, Palaiseau (20 min)
Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator
Carine TISNE, IBPC, Paris (20 min)
Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs
Julien MARQUEVIELLE, IECB/ARNA, Bordeaux (20 min)
NMR study of a RNA G-quadruplex forming sequence within HIV-1 U3 region
Evening : Welcome cocktail
Tuesday 30th November
8:30 Macromolecular Assemblies
Chair : Drs PLISSON-CHASTAING et COUREUX
Xiaojing CONG, IGF, Montpellier (30 min)
Molecular insights into the biased signaling mechanism of the μ-opioid receptor
Stéphane ROCHE, I2BC, Gif-sur-Yvette (20 min)
High Resolution CryoEM Structure and Assembly Mechanism of a Bacterial Virus Genome Gatekeeper
Lu YANG, Institut Pasteur, Paris (20 min)
The actinobacterial exception: 2.3 Å resolution cryo-EM structure of a large enzymatic machinery from a central metabolic supercomplex
Sayma ZAHID, I2BC, Gif-sur-Yvette (20 min)
Structural and functional study of the complex formed by the Werner protein (WRN) and the Ku70/Ku80 heterodimer
Helgo SCHMIDT, IGBMC, Illkirch (20 min)
The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1
10:30 Coffee break
11:00 Health issues I
Chair: Dr Gaudin
Juan REGUERA, AFMB, Marseille (30 min)
Rémi FRONZES, IECB, Bordeaux (30 min)
Rania GHOUIL, I2BC, Gif-sur-Yvette (20 min)
A cryptic motif in BRCA2 triggers oligomerization of the meiotic HSF2BP, as characterized by NMR, X-ray crystallography and cryo-electron microscopy
Xavier HANOULLE, Integrative Structural Biology Lab, Lille (20 min)
NMR of SARS-CoV-2 Main Protease (3CLpro) for drug development
Célia CAILLET-SAGUY, Institut Pasteur, Paris (20 min)
Host PDZ-containing proteins targeted by Hepatitis B virus and SARS-CoV-2
13:00 Lunch
13:45 Poster session
14:30 Sponsor presentation
15:00 Keynote
Jonas RIES, EMBL, Heidelberg, Germany
Superresolution microscopy for structural cell biology
15:30 Formation en continue
Chair: Dr Le Du
Sandrine DELACROIX-MORVAN, France Université Numérique
Fabrice CORDELIERE, France Bio Imaging
Dominique HOUSSET, French Infrastructure for Integrated Biology
Wednesday 1st December
8:30 Integral & peripheral membrane proteins
Chair: Drs Margeat and Czjzek
Agata NAWROTEK, ENS Paris-Saclay, Gif-sur-Yvette (30 min)
Regulation of small GTPase signaling at the periphery of membrane
Vincent CHAPTAL, IBCP, Lyon (20 min)
CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, Nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer
Laurent CATOIRE, IBPC, Paris (20 min)
Study of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure
Robert QUAST, CBS, Montpellier (20 min)
Dissecting the allosteric modulation of the Metabotropic Glutamate Receptor 2 using single molecule FRET
Guillaume Lebon, IGF, Montpellier (20 min)
Structural basis of the human mGlu5 receptor activation mechanism
10:30 Coffee break
11:00 Non-membrane compartmentalization
Chair: Dr Ruff
Andrea PARMEGGIANI, L2C, Montpellier (30 min)
Stefan AROLD, KAUST, Thuwal, Arabie Saoudite (20 min)
Kinase control through a highly disordered dimerization and calmodulin-binding element
Quentin NEVERS, I2BC, Gif-sur-Yvette (20 min)
Identification of structural elements required for the formation of rabies virus phosphoprotein and nucleoprotein inclusions in different minimal systems
Christina SIZUN, ICSN, Gif-sur-Yvette (20 min)
A structural and dynamic analysis of a viral platform protein
Marjolaine NOIRCLERC-SAVOYE, IBS, Grenoble (20 min)
HIV-1 Rev bound to human Importin beta : an integrative study of a protein complex
13:00 Lunch
13:45 Poster session
14:30 Sponsor presentation
15:00 Keynote
Simon ALBERTI, Max Planck Institute, Dresden, Germany
Biomolecular condensates at the nexus of cellular stress, aging and disease
15:30 Drug design
Chair: Dr Berger
Maria DUCA, ICN, Nice (30 min)
Axel INNIS, IECB, Bordeaux (30 min)
Context-dependent inhibition of protein synthesis by ribosome-targeting antibiotics
Laurent MAVEYRAUD, IPBS, Toulouse (20 min)
Inhibition of mycobacterial phosphopantetheinyl transferases
Magali MATHIEU, SANOFI, Vitry-sur-Seine (20 min)
KRAS G12C fragment screening renders new binding pockets
Eric ENNIFAR, Unistra, Strasbourg (20 min)
New drug design opportunities provided by Thermodynamics of Macrolide and PrAMP antibiotics binding to the bacterial ribosome provide
17:30 Discussion
Olivier NOSJEAN, Research Scientific Director, Servier, Croissy-sur-Seine
Darren HART, FRISBI, director Grenoble Center and Director of Integrated Structural Biology Grenoble (ISBG), IBS, Grenoble
Hélène CHAUTARD, Directrice du pôle science de la vie, de la Direction de l’Investissement de la SATT Paris-Saclay
Claude Nogues, Directrice Scientifique de Kimialys, Paris
Thursday 2nd December
8:30 Health issues II
Chair: Drs Pedelacq and Izadi
Alain MARTY, LISBP, Toulouse (30 min)
Oriane FRANCES, Sanofi, Vitry-sur-Seine (30 min)
Marc LENSINK, Lille (20 min)
The CAPRI covid-19 Open Science Initiative
Faustine HENOT, IBS, Grenoble (20 min)
Human HSP90 a contortionist drug target : Modulation of its energy landscape upon ligand binding
Carlos A. ELENA-REAL, CBS, Montpellier
High-resolution characterization of pathogenic and non-pathogenic Huntingtin protein poly-Q tracts
10:30 Coffee break
11:00 Methodologies I
Chair: Drs Gabelica and Czjzek
Sabine HEDIGER, IRIG, Grenoble (30 min)
Unraveling binding sites by selective DNP-enhanced NMR
Claude SAUTER, Unistra, Strasbourg (20 min)
Serial crystallography: a game-changer in crystallization and crystal handling
Martin WEIK, IBS, Grenoble
Photoenzyme at work: Structural dynamics of fatty acid photodecarboxylase
Marie LEY, Unistra, Strasbourg
Integration of mass spectrometry data to structural biology for the characterization of PRMT2/RSF1 interaction
12:30 Keynote
Irina GUTSCHE, IBS, Grenoble
13:00 Lunch
13:45 Poster session
14:30 General assembly
15:00 SFB Prize 2019
Emmanuelle BIGNON, Biochemistry Department, Université Nice Sophia Antipolis, Nice
Understanding the dynamics and reactivity of nucleic acids to fight against pathologies
Sélection 2021
Evening : Gala dinner
Friday 3rd December
8:30 Methodologies II
Chair: Dr Lescop
Sigrid MILLES, IBS, Grenoble (30 min)
Analysing the conformational landscape of IDPs by integrated NMR and smFRET
Florent DELHOMMEL, Bavarian Nmr Center, Technical University Of Munich / Institute Of Structural Biology, Germany (20 min)
NMR and structural characterization of NudC, a co-chaperone involved in client-transfer between heat shock proteins
Adeline ROBIN, IBS, Grenoble (20 min)
Fragment-based drug discovery on lactate dehydrogenase crystals grown in presence of Crystallophore.
Leo CHAVAS, Nagoya University, Synchrotron Radiation Research Center, Japan (20 min)
Combining expert methods for multi-scale and correlated analysis
Angela MANTOVANELL, IBS, Grenoble (20 min)
The Photoswitching Mechanism of the Fluorescent Protein rsEGFP2 at Cryogenic Temperature
10:00 Coffee break
10:30 Infrastructures
Chair: Dr Robert
Eric GUITTET,
Chargé de mission Secteur Biologie Santé, Ministère en charge de l’enseignement supérieur et de la recherche)
Daniel BOUJARD,
Directeur Adjoint Scientifique (DAS) du pôle Infrastructures nationales, Plateformes de l’INSB, CNRS
Jean-Pierre SIMORRE,
Délégué scientifique des grandes infrastructures de recherche de l’INC, CNRS
Bruno KLAHOLZ,
Responsable de l’infrastructure FRISBI
Carine VAN HEIJENOORT,
Responsable de l’Infrastructure InfrAnalytics
Béatrice SATIAT-JEUNEMAITRE,
Représentante FBI
13:00 Lunch
13:45 Conclusion
14:00-16:00 Satellite session Alphafold
Chair:
Randy READ
Laurent TERRADOT
Raphaël GUEROIS
Irène BARBARIN