2nd INTEGRATIVE STRUCTURAL BIOLOGY MEETING
November 29th to December 3rd 2021
Simon Alberti is a Professor at the Biotechnology Center (BIOTEC), Technische Universität Dresden in Germany. He received his PhD in 2004 in Cell Biology from the University of Bonn, Germany. From 2005-2009 he worked in the lab of Susan Lindquist at the Whitehead Institute for Biomedical Research (Cambridge, USA), where he worked on prions and amyloids in budding yeast. From 2010 to 2019 he was a research group leader at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, studying proteostasis and the molecular principles underlying cytoplasmic organization. His recent work shows that cells form many membraneless compartments via a biophysical process known as phase separation. Importantly, the ability to form such compartments becomes detrimental with increasing age, because compartment-forming proteins have a tendency to misfold and aggregate and thus are closely tied to the pathogenesis associated with age-related neurodegenerative diseases such as ALS.
Jonas Ries studied physics in Bremen and Konstanz and completed his PhD in Biophysics at the TU Dresden in the group of Petra Schwille, where he developed new methods to measure dynamics in artificial and cellular membranes. As a Postdoctoral Fellow at the ETH Zurich in the group of Vahid Sandoghdar he established single-molecule localization based superresolution microscopy and developed an efficient and simple labeling scheme for this method. In 2012 he joined the EMBL in Heidelberg as a group leader. The Ries group develops superresolution microscopy technologies to visualize the structure and dynamics of protein machines on the nanoscale in fixed and living cells. One main focus of the group is to use these techniques to investigate the dynamic structural organization of the machinery that drives clathrin-mediated endocytosis.
Irina Gutsche is currently the leader of the Microscopic Imaging of Complex Assemblies group in the IBS Grenoble. In the last year of her PhD thesis on actin assembly in LEBS, Gif-sur-Yvette, under the guidance of Marie-France Carlier, she had a chance to work with Jean Lepault, one of the pioneers of cryo-electron microscopy. Fascinated by the beauty of the images, she then got a thorough training in cryo-electron microscopy and tomography in the lab of Professor Baumeister in the Max Planck Institute of Biochemistry in Martinsried, where she worked on structure-function relationships of an archaeal chaperone system. As she returned to France, she combined her different areas of expertise and developed a research program focusing on structure, assembly and dynamics of flexible biological polymers and macromolecular complexes involved in particular in cellular stress response.
Andrea Carfi holds a PhD in Biophysics from the Université Joseph Fourier in Grenoble. He also trained as a postdoctoral fellow in the labs of Stephen Harrison and Don Wiley at Boston Children’s Hospital/Harvard. Dr. Carfi has more than 15 years of experience in drug discovery and vaccine development at Moderna, GSK, Novartis Vaccines and IRBM/Merck. He has covered roles of increasing responsibility with a focus on structural biology, antigen design, small molecule antivirals discovery and vaccines development. Dr. Carfi joined Moderna in 2017 as Head of Antigen Design and Selection and Project Leader for the CMV vaccine program and has become the Head of Research for Infectious Disease at Moderna since 2019. He is currently leading Research for all Moderna Infectious Disease targets.